Pan-immune-inflammation value and systemic immune-inflammation index: Are they useful markers in sarcoidosis?

Background/Aim: Sarcoidosis is a multisystem inflammatory disease characterized by the infiltration of various organs. Due to lack widely-accepted biomarker, researchers have explored alternative and previously unexplored parameters in sarcoidosis. This study aimed investigate utility markers, including systemic immune-inflammation index (SII) pan-immune-inflammation value (PIV), patients with Methods: A case-control was conducted between January 2019 February 2023. The included 75 diagnosed sarcoidosis, 93 healthy individuals matched for age, sex, body mass index. Sarcoidosis-related features, such as lung stage extrapulmonary involvement, were recorded. investigated SII, PIV, procalcitonin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), other biochemical results, complete blood counts (including neutrophil, lymphocyte, monocyte, platelet counts, hemoglobin, mean volume [MPV], red cell distribution width [RDW]). Results: age sex similar both case control groups (P=0.258 P=0.196, respectively). patient group had significantly lower absolute lymphocyte count than (P=0.035). Patients’ RDW (P=0.007), platelet-to-lymphocyte ratio (P=0.028), ESR (P<0.001) values higher compared controls. No significant difference observed two regarding variables, PIV SII. There weak positive correlation stage, well MPV presence erythema nodosum. Conclusion: SII sarcoidosis correlations nodosum suggest potential relationships sarcoidosis-related features demonstrate these readily available inexpensive markers management. Comprehensive studies are needed clarify whether and/or can be used assess characteristics